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Prostaglandins, specifically PGE 2 , have been shown to increase in irradiated salivary glands, and mitigation of salivary gland damage was achieved with the anti-inflammatory drug Indomethacin 1,87

In the results of a cohort study published in BMJ, new users of GLP-1 receptor agonists had a 30% lower risk of severe COPD exacerbation compared to new sulfonylurea users

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While IGF1 LR3 itself is not carcinogenic, the growth-promoting effects of IGF-1 signaling raise theoretical concerns about long-term exposure